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Article

Integrity of the methylation cycle is essential for mammalian neural tube closure

1 Jul 2006

Abstract excerpt

BACKGROUND: Closure of the cranial neural tube during embryogenesis is a crucial process in development of the brain. Failure of this event results in the severe neural tube defect (NTD) exencephaly, the developmental forerunner of anencephaly. METHODS: The requirement for methylation cycle function in cranial neural tube closure was tested by treatment of cultured mouse embryos with cycloleucine or ethionine,...

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PMID: 16933307
DOI: 10.1002/bdra.20286

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