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Article

Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos.

FEBS letters - 15 May 2006

Dunlevy Louisa P E, Burren Katie A, Chitty Lyn S, Copp Andrew J, Greene Nicholas D E

Abstract excerpt

Suppression of one-carbon metabolism or insufficient methionine intake are suggested to increase risk of neural tube defects (NTD). Here, exogenous methionine unexpectedly caused frequent NTD in cultured mouse embryos. NTD were associated with reduced cranial mesenchyme cell density, which may result from a preceding reduction in proliferation. The abundance ratio of S-adenosylmethionine to S-adenosylhomocysteine...

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Identifiers

PMID: 16674949
DOI: 10.1016/j.febslet.2006.04.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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