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Article

Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.

The American journal of clinical nutrition - 1 Apr 2011

Beaudin Anna E, Abarinov Elena V, Noden Drew M, Perry Cheryll A, Chu Stephanie, Stabler Sally P, Allen Robert H, Stover Patrick J

Abstract excerpt

BACKGROUND: Folic acid supplementation prevents the occurrence and recurrence of neural tube defects (NTDs), but the causal metabolic pathways underlying folic acid-responsive NTDs have not been established. Serine hydroxymethyltransferase (SHMT1) partitions folate-derived one-carbon units to thymidylate biosynthesis at the expense of cellular methylation, and therefore SHMT1-deficient mice are a model to...

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Source

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Identifiers

PMID: 21346092
DOI: 10.3945/ajcn.110.002766
PMCID: PMC3057548

Genes

SHMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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