Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Embryonic folate metabolism and mouse neural tube defects.

Science (New York, N.Y.) - 26 Jun 1998

Fleming A, Copp A J

Abstract excerpt

Folic acid prevents 70 percent of human neural tube defects (NTDs) but its mode of action is unclear. The deoxyuridine suppression test detects disturbance of folate metabolism in homozygous splotch (Pax3) mouse embryos that are developing NTDs in vitro. Excessive incorporation of [3H]thymidine in splotch embryos indicates a metabolic deficiency in the supply of folate for the biosynthesis of pyrimidine....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to DNA-Binding Proteins
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Folic Acid

Share to Methionine

Share to Mice, Inbred CBA

Share to Mutation

Source

Identifiers

PMID: 9641914
DOI: 10.1126/science.280.5372.2107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Embryonic folate metabolism and mouse neural tube defects.PMID 9641914Read ↗

Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.Semantic proximity Read ↗

Understanding the causes and prevention of neural tube defects: Insights from the <i>splotch</i> mouse modelSemantic proximity Read ↗

Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.Semantic proximity Read ↗

Neural Tube Defects, Folic Acid and MethylationSemantic proximity Read ↗

Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acidSemantic proximity Read ↗

Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouseSemantic proximity Read ↗

The genetic basis of mammalian neurulation.Semantic proximity Read ↗

Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients.Semantic proximity Read ↗

Neural tube defects and folate: case far from closed.Semantic proximity Read ↗

Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice.Semantic proximity Read ↗

Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutantsSemantic proximity Read ↗

Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.