Embryonic folate metabolism and mouse neural tube defects.

doi:10.1126/science.280.5372.2107

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Article

Embryonic folate metabolism and mouse neural tube defects.

Science (New York, N.Y.) - 26 Jun 1998

Fleming A, Copp A J

Abstract excerpt

Folic acid prevents 70 percent of human neural tube defects (NTDs) but its mode of action is unclear. The deoxyuridine suppression test detects disturbance of folate metabolism in homozygous splotch (Pax3) mouse embryos that are developing NTDs in vitro. Excessive incorporation of [3H]thymidine i...

Topics

Animals
Central Nervous System
DNA-Binding Proteins
Deoxyuracil Nucleotides
Embryo, Mammalian
Female
Folic Acid
Humans
Male
Methionine
Mice
Mice, Inbred CBA
Mutation
Neural Tube Defects
PAX3 Transcription Factor
Paired Box Transcription Factors
Pyrimidines
Tetrahydrofolates

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