Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid

Abstract excerpt

Neural tube defects (NTDs), including spina bifida and anencephaly, are among the most common birth defects worldwide but the underlying genetic and cellular causes are not well understood. Some NTDs are preventable by supplemental folic acid. However, the protective mechanism is unclear despite widespread use of folic acid supplements and implementation of food fortification in many countries. Pax3 mutant...

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