Article
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.
Human molecular genetics - 1 Dec 2008
Burren Katie A, Savery Dawn, Massa Valentina, Kok Robert M, Scott John M, Blom Henk J, Copp Andrew J, Greene Nicholas D E
Abstract excerpt
Risk of neural tube defects (NTDs) is determined by genetic and environmental factors, among which folate status appears to play a key role. However, the precise nature of the link between low folate status and NTDs is poorly understood, and it remains unclear how folic acid prevents NTDs. We investigated the effect of folate level on risk of NTDs in splotch (Sp(2)(H)) mice, which carry a mutation in Pax3....
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