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Article

Inhibiting MARSs reduces hyperhomocysteinemia‐associated neural tube and congenital heart defects

31 Jan 2020

Abstract excerpt

Hyperhomocysteinemia is a common metabolic disorder that imposes major adverse health consequences. Reducing homocysteine levels, however, is not always effective against hyperhomocysteinemia-associated pathologies. Herein, we report the potential roles of methionyl-tRNA synthetase (MARS)-generated homocysteine signals in neural tube defects (NTDs) and congenital heart defects (CHDs). Increased copy numbers of...

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PMID: 32003121
DOI: 10.15252/emmm.201809469

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