Article
De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4.
The Journal of investigative dermatology - 1 Feb 2007
Grinnell Katie L, Yang Baoli, Eckert Richard L, Bickenbach Jackie R
Abstract excerpt
The embryonic transcription factor Oct-4 is often referred to as the master regulator of the undifferentiated state. Although its role in maintaining embryonic stem (ES) cell pluripotency is well established, its ability to directly reprogram committed somatic cells is not well defined. Using transient transfection, we tested its ability to revert mouse interfollicular epidermal basal keratinocytes to a more ES...
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