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Increase developmental plasticity of human keratinocytes with gene suppression

18 Jul 2011

Abstract excerpt

Recent evidence indicates that p53 suppression increased the efficiency of induced pluripotent stem cell (iPSC) generation. This occurred even with the enforced expression of as few as two canonical transcription factors, Oct4 and Sox2. In this study, primary human keratinocytes were successfully induced into a stage of plasticity by transient inactivation of p53, without enforced expression of any of the...

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PMID: 21768375
DOI: 10.1073/pnas.1100509108

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