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Pluripotency factor Nanog is tumorigenic by deregulating DNA damage response in somatic cells.

Oncogene - 10 Mar 2016

Kim J, Liu Y, Qiu M, Xu Y

Abstract excerpt

The pluripotency gene Nanog is not expressed in normal adult tissues but is overexpressed in some human cancers. However, the tumorigenic roles of Nanog remain unclear. The ectopic expression of Nanog is not sufficient to induce spontaneous tumors in mice but can promote metastasis of established tumors by activating the expression of metastatic genes. The expression of Nanog in mouse skin activates tumor...

Topics

Animals
Carcinogenesis
Cell Differentiation
DNA Breaks, Double-Stranded
DNA Damage
Ectopic Gene Expression
Epidermis
Homeodomain Proteins
Humans
Mice
Nanog Homeobox Protein
Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Pluripotent Stem Cells

Source

Identifiers

PMID: 26073077
DOI: 10.1038/onc.2015.205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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