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Successful Therapy Must Eradicate Cancer Stem Cells

25 Aug 2006

Abstract excerpt

Despite significant improvements in cancer therapy, tumor recurrence is frequent and can be due to a variety of mechanisms, including the evolution of resistance and tumor progression. Cancer stem cells have been postulated to maintain tumor growth similar to normal stem cells maintaining tissue homeostasis. Recently, the existence of these malignant stem cells has been proven for hematological as well as some...

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PMID: 16931775
DOI: 10.1634/stemcells.2006-0136

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