New hope for cancer treatment: exploring the distinction between normal adult stem cells and cancer stem cells.

doi:10.1016/j.pharmthera.2008.04.008

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Article

New hope for cancer treatment: exploring the distinction between normal adult stem cells and cancer stem cells.

Pharmacology & therapeutics - 1 Jul 2008

Zhao Robert Chunhua, Zhu Ya-Shu, Shi Yufang

Abstract excerpt

For decades, intensive studies have attempted to identify the mechanisms underlying malignant tumor growth. Despite significant progress, most therapeutic approaches fail to eliminate all tumor cells. The remaining tumor cells often result in recurrence and metastasis. Recently, the idea of a cancer stem cell was proposed to explain of the origin of cancer cells. According to this hypothesis, a small fraction of...

Topics

Adult Stem Cells
Animals
Cell Differentiation
Hedgehog Proteins
Humans
Neoplasms
Neoplastic Stem Cells
Phenotype
Receptors, Notch
Signal Transduction
Wnt Proteins

Source

Open in PubMed

Identifiers

PMID: 18562010
DOI: 10.1016/j.pharmthera.2008.04.008

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