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Article

Role of the COP1 protein in cancer development and therapy.

Seminars in cancer biology - 1 Dec 2020

Song Yizuo, Liu Yi, Pan Shuya, Xie Shangdan, Wang Zhi-Wei, Zhu Xueqiong

Abstract excerpt

COP1, an E3 ubiquitin ligase, has been demonstrated to play a vital role in the regulation of cell proliferation, apoptosis and DNA repair. Accumulated evidence has revealed that COP1 is involved in carcinogenesis via targeting its substrates, including p53, c-Jun, ETS, β-catenin, STAT3, MTA1, p27, 14-3-3σ, and C/EBPα, for ubiquitination and degradation. COP1 can play tumor suppressive and oncogenic roles in...

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Source

Identifiers

PMID: 32027978
DOI: 10.1016/j.semcancer.2020.02.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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