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Article

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress

8 Apr 2004

Abstract excerpt

Ataxia-telangiectasia (A-T) is a syndrome of cancer susceptibility, immune dysfunction, and neurodegeneration that is caused by mutations in the A-T-mutated (ATM) gene. ATM has been implicated as a critical regulator of cellular responses to DNA damage, including the activation of cell cycle checkpoints and induction of apoptosis. Although defective cell cycle-checkpoint regulation and associated genomic...

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PMID: 15073328
DOI: 10.1073/pnas.0307718101

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