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Article

Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.

Molecular and cellular biology - 1 Sept 2009

McKeegan Kenneth Scott, Debieux Charles Maurice, Watkins Nicholas James

Abstract excerpt

The box C/D small nucleolar RNPs (snoRNPs) are essential for the processing and modification of rRNA. TIP48 and TIP49 are two related AAA(+) proteins that are essential for the formation of box C/D snoRNPs. These proteins are key components of the pre-snoRNP complexes, but their exact role in box...

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Source

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Identifiers

PMID: 19620283
DOI: 10.1128/MCB.00752-09
PMCID: PMC2738292

Genes

NOP56
NOP58

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19620283-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.PMID 19620283Read ↗

Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.Semantic proximity Read ↗

The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.Semantic proximity Read ↗

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.Semantic proximity Read ↗

Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.Semantic proximity Read ↗

Utp14 interaction with the small subunit processome.Semantic proximity Read ↗

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin.Semantic proximity Read ↗

A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.Semantic proximity Read ↗

hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.Semantic proximity Read ↗

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.Semantic proximity Read ↗

The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae.Semantic proximity Read ↗

The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles.Semantic proximity Read ↗

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