Article
An altered IGF-I receptor is present in human leukemic cells.
The Journal of biological chemistry - 5 Jun 1990
Kellerer M, Obermaier-Kusser B, Ermel B, Wallner U, Häring H U, Petrides P E
Abstract excerpt
We have characterized and analyzed IGF-I- and insulin-stimulated cell growth, receptor binding, and autophosphorylation in the human leukemic cell line HL-60. IGF-I-stimulated cell growth occurred at low (5 ng/ml) and insulin stimulated only at high (500 ng/ml) concentrations. Binding of 125I-IGF...
Topics
- Cell Division
- Cell Membrane
- Chromatography, High Pressure Liquid
- Cross-Linking Reagents
- Fetus
- Genetic Variation
- Glycosylation
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Leukemia, Promyelocytic, Acute
- Molecular Weight
- Peptide Mapping
- Phosphorylation
- Phosphothreonine
- Phosphotyrosine
- Receptors, Cell Surface
- Receptors, Somatomedin