Article
Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines.
Cancer research - 15 Jun 1994
Freund G G, Kulas D T, Way B A, Mooney R A
Abstract excerpt
While IGF-1 plays a role in early B-cell development, little is known of insulin and insulin-like growth factor-1 (IGF-1) action in post-marrow B-cells. Recently, our laboratory demonstrated that mouse and human multiple myeloma (MM) cell lines possess functional insulin receptors (IRs) and IGF-1...
Topics
- Animals
- B-Lymphocytes
- Burkitt Lymphoma
- Cell Line
- Herpesvirus 4, Human
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Mice
- Multiple Myeloma
- Phenotype
- Phosphorylation
- Receptor, IGF Type 1
- Receptor, Insulin
- Signal Transduction
- Tumor Cells, Cultured