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Article

IGF‐II Binding to Insulin Receptor Isoform A Induces a Partially Different Gene Expression Profile from Insulin Binding

1 Dec 2004

Abstract excerpt

Insulin receptor isoform A (IR-A) is a fetal insulin receptor isoform that is overexpressed in cancer. We investigated whether insulin-like growth factor (IGF)-II may elicit a different gene expression response from insulin in cells expressing only IR-A and lacking IGF-I receptor (R-/IR-A cells). Cells were stimulated with either insulin or IGF-II (at 0.5, 3, and 8 h), and global gene expression was studied by...

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Identifiers

PMID: 15650270
DOI: 10.1196/annals.1322.053

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