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Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor

23 Dec 2015

Abstract excerpt

BACKGROUND: IGF1 is a key regulator of tissue growth and development and has been implicated in the initiation and progression of various cancers, including breast cancer. Through IGF1 mRNA splicing different precursor pro-peptides, i.e., the IGF1Ea, IGF1Eb and IGF1Ec pro-forms, are formed whose biological roles in the pathogenesis of breast cancer have not been established yet. The objective of this study was to...

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PMID: 26701791
DOI: 10.1007/s13402-015-0263-3

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