Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant.

doi:10.1172/JCI116096

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Article

Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant.

The Journal of clinical investigation - 1 Nov 1992

Prager D, Yamasaki H, Weber M M, Gebremedhin S, Melmed S

Abstract excerpt

Hybrid receptors were studied in GC rat pituitary cells overexpressing either wild-type 950Tyr (WT) human insulin-like growth factor I (IGF-I) receptors or mutant human IGF-I receptors truncated at position 952 in the beta subunit transmembrane region (952STOP). 125I-IGF-I binding was increased i...

Topics

Animals
Base Sequence
Cell Line
Half-Life
Humans
Molecular Sequence Data
Mutation
Phosphorylation
Pituitary Gland
Rats
Receptor, IGF Type 1

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