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Article

Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant.

The Journal of clinical investigation - 1 Nov 1992

Prager D, Yamasaki H, Weber M M, Gebremedhin S, Melmed S

Abstract excerpt

Hybrid receptors were studied in GC rat pituitary cells overexpressing either wild-type 950Tyr (WT) human insulin-like growth factor I (IGF-I) receptors or mutant human IGF-I receptors truncated at position 952 in the beta subunit transmembrane region (952STOP). 125I-IGF-I binding was increased in both 950Tyr (WT) (14-fold) and truncated human IGF-I receptor (952STOP) stable transfectants (50-fold), when compared...

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Identifiers

PMID: 1430235
DOI: 10.1172/JCI116096
PMCID: PMC443280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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