Article
Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls.
Human immunology - 1 Jan 2000
Noble Janelle A, Martin Adelle, Valdes Ana M, Lane Julie A, Galgani Andrea, Petrone Antonio, Lorini Renata, Pozzilli Paolo, Buzzetti Raffaella, Erlich Henry A
Abstract excerpt
Patients with high-risk human leukocyte antigen (HLA)-DR-DQ genotypes for type 1 diabetes (T1D) were compared with HLA-matched controls to evaluate T1D risk for other HLA loci, including HLA-A, -B, -Cw, and DPB1. Patients (n = 133) with high-risk genotypes (DR3/DR3, DR3/DR4, DR4/DR4) were selected from the Lazio (Rome) region of Italy. Screening of more than 9000 patients from the Lazio region and northern Italy...
Topics
- Case-Control Studies
- Diabetes Mellitus, Type 1
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-A Antigens
- HLA-A1 Antigen
- HLA-B Antigens
- HLA-B8 Antigen
- HLA-DP Antigens