Article
"Extended" A1, B8, DR3 haplotype shows remarkable linkage disequilibrium but is similar to nonextended haplotypes in terms of diabetes risk.
Diabetes - 1 Jun 2005
Ide Akane, Babu Sunanda R, Robles David T, Wang Tianbao, Erlich Henry A, Bugawan Teodorica L, Rewers Marian, Fain Pamela R, Eisenbarth George S
Abstract excerpt
To evaluate potential differential diabetes risk of DR3 haplotypes we have evaluated class I alleles as well as two microsatellites previously associated with differential risk associated with DR3 haplotypes. We found that over one-third of patient DR3 chromosomes consisted of an extended DR3 haplotype, from DQ2 to D6S2223 (DQ2, DR3, D6S273-143, MIC-A5.1, HLA-B8, HLA-Cw7, HLA-A1, and D6S2223-177) with an...
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