Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response.

Journal of virology - 1 Nov 2006

Hwang Irene I L, Watson Ian R, Der Sandy D, Ohh Michael

Abstract excerpt

Hypoxia-inducible factor (HIF) is a central regulator of cellular responses to hypoxia, and under normal oxygen tension the catalytic alpha subunit of HIF is targeted for ubiquitin-mediated destruction via the VHL-containing E3 ubiquitin ligase complex. Principally known for its association with oncogenesis, HIF has been documented to have a role in the antibacterial response. Interferons, cytokines with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Interferons

Share to RNA Interference

Share to Vesicular stomatitis Indiana virus

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 16928739
DOI: 10.1128/JVI.01014-06
PMCID: PMC1641802

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response.PMID 16928739Read ↗

The VHL tumor suppressor: master regulator of HIF.Semantic proximity Read ↗

Hypoxia-inducible factor 1 and its role in viral carcinogenesisSemantic proximity Read ↗

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.Semantic proximity Read ↗

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilitiesSemantic proximity Read ↗

Hypoxia and viral infectious diseasesSemantic proximity Read ↗

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.Semantic proximity Read ↗

The Positive Regulation of p53 by the Tumor Suppressor VHLSemantic proximity Read ↗

Kaposi's Sarcoma–Associated Herpesvirus Viral IFN Regulatory Factor 3 Stabilizes Hypoxia-Inducible Factor-1α to Induce Vascular Endothelial Growth Factor ExpressionSemantic proximity Read ↗

A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas.Semantic proximity Read ↗

Development of drugs targeting hypoxia-inducible factor against tumor cells with VHL mutation: Story of 127 years.Semantic proximity Read ↗

Ubiquitin Pathway in VHL Cancer SyndromeSemantic proximity Read ↗

VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.