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Article

VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1.

The Journal of cell biology - 6 Mar 2017

Labrousse-Arias David, Martínez-Alonso Emma, Corral-Escariz María, Bienes-Martínez Raquel, Berridy Jaime, Serrano-Oviedo Leticia, Conde Elisa, García-Bermejo María-Laura, Giménez-Bachs José M, Salinas-Sánchez Antonio S, Sánchez-Prieto Ricardo, Yao Masahiro, Lasa Marina, Calzada María J

Abstract excerpt

Vascular cell adhesion molecule 1 (VCAM-1) is an adhesion molecule assigned to the activated endothelium mediating immune cells adhesion and extravasation. However, its expression in renal carcinomas inversely correlates with tumor malignancy. Our experiments in clear cell renal cell carcinoma (ccRCC) cell lines demonstrated that von Hippel Lindau (VHL) loss, hypoxia, or PHD (for prolyl hydroxylase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

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Identifiers

PMID: 28235946
DOI: 10.1083/jcb.201608024
PMCID: PMC5350518

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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