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Article

Hypoxia-inducible factor 1 and its role in viral carcinogenesis

1 Apr 2014

Abstract excerpt

The advent of modern molecular biology has allowed for the discovery of several mechanisms by which oncoviruses promote carcinogenesis. Remarkably, nearly all human oncogenic viruses increase levels of the transcription factor hypoxia-inducible factor 1 (HIF-1). In this review, we highlight HIF-1׳s significance in viral oncogenesis, while providing an in-depth analysis of its activation mechanisms by the...

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PMID: 24698149
DOI: 10.1016/j.virol.2014.02.027

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