Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.

Molecular cancer research : MCR - 1 Feb 2004

Zimmer Michael, Doucette Darrell, Siddiqui Naila, Iliopoulos Othon

Abstract excerpt

The von Hippel-Lindau tumor suppressor protein (pVHL) is a substrate receptor for the mammalian SCF-2 E3 ubiquitin ligase complex that targets several substrates for ubiquitination and proteasomal degradation. Among these targets are the alpha-regulatory subunits of the hypoxia-inducible factor (HIF). VHL-/- cells constitutively overexpress hypoxia-inducible genes through both transcriptional and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Hypoxia

Share to Neovascularization, Pathologic

Share to Umbilical Veins

Share to Vascular Endothelial Growth Factor A

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 14985465

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.PMID 14985465Read ↗

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.Semantic proximity Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

The VHL tumor suppressor: master regulator of HIF.Semantic proximity Read ↗

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.Semantic proximity Read ↗

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.Semantic proximity Read ↗

The Positive Regulation of p53 by the Tumor Suppressor VHLSemantic proximity Read ↗

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.Semantic proximity Read ↗

Role of VHL gene mutation in human cancer.Semantic proximity Read ↗

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.Semantic proximity Read ↗

Ubiquitin Pathway in VHL Cancer SyndromeSemantic proximity Read ↗

Systemic <i>VHL</i> gene functions and the VHL diseaseSemantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.