Article
Development of drugs targeting hypoxia-inducible factor against tumor cells with VHL mutation: Story of 127 years.
Cancer science - 1 Apr 2023
Takamori Hajime, Yamasaki Toshinari, Kitadai Rui, Minamishima Yoji Andrew, Nakamura Eijiro
Abstract excerpt
Intratumoral hypoxia is associated with tumor progression and therapeutic resistance. The VHL tumor suppressor gene was identified in 1993, and later studies revealed that the gene product pVHL interacts with other proteins to form the VBC complex. The VBC complex functions as an E3 ubiquitin ligase and regulates the abundance of the α-subunit of the transcription factor hypoxia-inducible factor (HIF)....
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