Article
Intron length and accelerated 3' gene evolution.
Genomics - 1 Dec 2006
Tang Clara S, Zhao Yong Z, Smith David K, Epstein Richard J
Abstract excerpt
Genetic evolution depends in part upon a balance between negative selection and environmentally driven mutation. To explore whether this balance is affected by gene structure, we have used phylogenetic data mining to compare gene compositions across a range of species. Here we show that genomes of higher species exhibit a greater frequency of 5' CpG islands and of CpG-->TpG/CpA transitions. This latter mutational...
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