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Article

The evolution of transcription-associated biases of mutations across vertebrates.

BMC evolutionary biology - 18 Jun 2010

Polak Paz, Querfurth Robert, Arndt Peter F

Abstract excerpt

BACKGROUND: The interplay between transcription and mutational processes can lead to particular mutation patterns in transcribed regions of the genome. Transcription introduces several biases in mutational patterns; in particular it invokes strand specific mutations. In order to understand the forces that have shaped transcripts during evolution, one has to study mutation patterns associated with transcription...

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PMID: 20565875
DOI: 10.1186/1471-2148-10-187
PMCID: PMC2927911

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