Article
Complex selection on 5' splice sites in intron-rich organisms.
Genome research - 1 Nov 2009
Irimia Manuel, Roy Scott William, Neafsey Daniel E, Abril Josep F, Garcia-Fernandez Jordi, Koonin Eugene V
Abstract excerpt
In contrast to the typically streamlined genomes of prokaryotes, many eukaryotic genomes are riddled with long intergenic regions, spliceosomal introns, and repetitive elements. What explains the persistence of these and other seemingly suboptimal structures? There are three general hypotheses: (1) the structures in question are not actually suboptimal but optimal, being favored by selection, for unknown reasons;...
Topics
- Animals
- Base Sequence
- Consensus Sequence
- Cryptococcus
- Cryptococcus neoformans
- Drosophila
- Drosophila melanogaster
- Evolution, Molecular
- Genetic Variation
- Introns
- Macaca