Article
Evolutionarily conserved genes preferentially accumulate introns.
Genome research - 1 Jul 2007
Carmel Liran, Rogozin Igor B, Wolf Yuri I, Koonin Eugene V
Abstract excerpt
Introns that interrupt eukaryotic protein-coding sequences are generally thought to be nonfunctional. However, for reasons still poorly understood, positions of many introns are highly conserved in evolution. Previous reconstructions of intron gain and loss events during eukaryotic evolution used a variety of simplified evolutionary models that yielded contradicting conclusions and are not suited to reveal some...
Topics
- Animals
- Conserved Sequence
- Evolution, Molecular
- Exons
- Genes
- Genetic Variation
- Genetics, Population
- Introns
- Kinetics
- Models, Genetic
- Proteins
- RNA Splicing
- Time