Article
Androgen receptor mutations in high-grade prostate cancer before hormonal therapy.
Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2003
Thompson James, Hyytinen Eija-Riitta, Haapala Kyllikki, Rantala Immo, Helin Heikki J, Jänne Olli A, Palvimo Jorma J, Koivisto Pasi A
Abstract excerpt
Androgen action is mediated through androgen receptor (AR), which appears to undergo structural and functional alterations during prostate cancer (CaP) progression. AR mutations have been infrequently reported in CaP before hormonal therapy, but in untreated, advanced tumors AR mutations are suggested to be more common. To investigate the frequency of AR mutations in aggressive CaP before hormonal therapy, we...
Topics
- Adenocarcinoma
- DNA Mutational Analysis
- DNA, Neoplasm
- Humans
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prostatic Neoplasms
- Receptors, Androgen