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Article

Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells

22 Feb 2011

Abstract excerpt

Androgen receptor (AR) is expressed in all stages of prostate cancer progression, including in castration-resistant tumors. Eliminating AR function continues to represent a focus of therapeutic investigation, but AR regulatory mechanisms remain poorly understood. To systematically characterize mechanisms involving microRNAs (miRNAs), we conducted a gain-of function screen of 1129 miRNA molecules in a panel of...

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PMID: 21343391
DOI: 10.1158/0008-5472.can-10-2421

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