Article
Germline Mutations and Polymorphisms of Androgen Receptor in Prostate Cancer Patients: Frequency and Results of in Silico Analysis
Asian Pacific journal of cancer prevention : APJCP - 24 Aug 2018
Sribudiani Yunia, Marwan Deineke W, Aulanni’am Aulanni’am, Widodo Muhammad A, Purnomo Basuki B, Panigoro Ramdan, Utomo Ahmad B
Abstract excerpt
Background: Germline and somatic polymorphisms and mutations of the Androgen Receptor (AR) gene are known to be associated with the incidence of prostate cancer (PCa) in different populations. In this study we assessed germline AR polymorphisms and mutations in PCa patients with prediction of pathogenicity of the identified mutations by in silico analysis. Methods: Diagnosis of PCa was based on histopathology of...
Topics
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Follow-Up Studies
- Genotype
- Germ-Line Mutation
- Humans
- Indonesia
- Male
- Middle Aged
- Polymorphism, Genetic