Article
Rarity of DNA sequence alterations in the promoter region of the human androgen receptor gene.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Dec 2004
Cabral D F, Santos A, Ribeiro M L, Mesquita J C, Carvalho-Salles A B, Hackel C
Abstract excerpt
The human androgen receptor (AR) gene promoter lies in a GC-rich region containing two principal sites of transcription initiation and a putative Sp1 protein-binding site, without typical "TATA" and "CAAT" boxes. It has been suggested that mutations within the 5'untranslated region (5'UTR) may contribute to the development of prostate cancer by changing the rates of gene transcription and/or translation. In order...
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