Article
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.
Nature genetics - 1 Aug 2007
Zanke Brent W, Greenwood Celia M T, Rangrej Jagadish, Kustra Rafal, Tenesa Albert, Farrington Susan M, Prendergast James, Olschwang Sylviane, Chiang Theodore, Crowdy Edgar, Ferretti Vincent, Laflamme Philippe, Sundararajan Saravanan, Roumy Stéphanie, Olivier Jean-François, Robidoux Frédérick, Sladek Robert, Montpetit Alexandre, Campbell Peter, Bezieau Stephane, O'Shea Anne Marie, Zogopoulos George, Cotterchio Michelle, Newcomb Polly, McLaughlin John, Younghusband Ban, Green Roger, Green Jane, Porteous Mary E M, Campbell Harry, Blanche Helene, Sahbatou Mourad, Tubacher Emmanuel, Bonaiti-Pellié Catherine, Buecher Bruno, Riboli Elio, Kury Sebastien, Chanock Stephen J, Potter John, Thomas Gilles, Gallinger Steven, Hudson Thomas J, Dunlop Malcolm G
Abstract excerpt
Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle,...
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