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Article

Inferring direct regulatory targets from expression and genome location analyses: a comparison of transcription factor deletion and overexpression.

BMC genomics - 22 Aug 2006

Tang Lin, Liu Xiao, Clarke Neil D

Abstract excerpt

BACKGROUND: Effects on gene expression due to environmental or genetic changes can be easily measured using microarrays. However, indirect effects on expression can be substantial. The indirect effects of a perturbation need to be distinguished from the direct effects if we are to understand the structure and behavior of regulatory networks. RESULTS: The most direct way to perturb a transcriptional network is to...

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Identifiers

PMID: 16923194
DOI: 10.1186/1471-2164-7-215
PMCID: PMC1559704

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