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Article

Assigning function to natural allelic variation via dynamic modeling of gene network induction.

Molecular systems biology - 15 Jan 2018

Richard Magali, Chuffart Florent, Duplus-Bottin Hélène, Pouyet Fanny, Spichty Martin, Fulcrand Etienne, Entrevan Marianne, Barthelaix Audrey, Springer Michael, Jost Daniel, Yvert Gaël

Abstract excerpt

More and more natural DNA variants are being linked to physiological traits. Yet, understanding what differences they make on molecular regulations remains challenging. Important properties of gene regulatory networks can be captured by computational models. If model parameters can be "personalized" according to the genotype, their variation may then reveal how DNA variants operate in the network. Here, we...

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PMID: 29335276
DOI: 10.15252/msb.20177803
PMCID: PMC5787706

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Source receipt: pubmed, retrieved 7 Sept 2026.

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