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Article

Identifying transcription factor functions and targets by phenotypic activation.

Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006

Chua Gordon, Morris Quaid D, Sopko Richelle, Robinson Mark D, Ryan Owen, Chan Esther T, Frey Brendan J, Andrews Brenda J, Boone Charles, Hughes Timothy R

Abstract excerpt

Mapping transcriptional regulatory networks is difficult because many transcription factors (TFs) are activated only under specific conditions. We describe a generic strategy for identifying genes and pathways induced by individual TFs that does not require knowledge of their normal activation cues. Microarray analysis of 55 yeast TFs that caused a growth phenotype when overexpressed showed that the majority...

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Identifiers

PMID: 16880382
DOI: 10.1073/pnas.0605140103
PMCID: PMC1567694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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