Article
Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β.
European journal of immunology - 1 Jun 2015
Sarhan Dhifaf, Palma Marzia, Mao Yumeng, Adamson Lars, Kiessling Rolf, Mellstedt Håkan, Österborg Anders, Lundqvist Andreas
Abstract excerpt
Dendritic cell (DC) vaccines induce T-cell responses in cancer patients. However, there is a paucity of data regarding the role of DC vaccines in shaping natural killer (NK) cell responses. Here, we observe that NK cells are less activated following DC vaccination. In vitro, DC-mediated inhibition of NK cells did not require cell-to-cell contact, but required increased Signal transducer and activator of...
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