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Article

Monocyte derived dendritic cells generated by IFN-alpha acquire mature dendritic and natural killer cell properties as shown by gene expression analysis.

Journal of translational medicine - 25 Sept 2007

Korthals Mark, Safaian Nancy, Kronenwett Ralf, Maihöfer Dagmar, Schott Matthias, Papewalis Claudia, Diaz Blanco Elena, Winter Meike, Czibere Akos, Haas Rainer, Kobbe Guido, Fenk Roland

Abstract excerpt

BACKGROUND: Dendritic cell (DC) vaccines can induce antitumor immune responses in patients with malignant diseases, while the most suitable DC culture conditions have not been established yet. In this study we compared monocyte derived human DC from conventional cultures containing GM-CSF and IL-4/TNF-alpha (IL-4/TNF-DC) with DC generated by the novel protocol using GM-CSF and IFN-alpha (IFN-DC). METHODS: To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17894866
DOI: 10.1186/1479-5876-5-46
PMCID: PMC2064912

Genes

TNF
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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