Article
Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma.
Blood - 1 Oct 2008
Dhodapkar Kavita M, Barbuto Scott, Matthews Phillip, Kukreja Anjli, Mazumder Amitabha, Vesole David, Jagannath Sundar, Dhodapkar Madhav V
Abstract excerpt
IL17-producing (Th17) cells are a distinct lineage of T helper cells that regulate immunity and inflammation. The role of antigen-presenting cells in the induction of Th17 cells in humans remains to be fully defined. Here, we show that human dendritic cells (DCs) are efficient inducers of Th17 cells in culture, including antigen-specific Th17 cells. Although most freshly isolated circulating human Th17 cells...
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