Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats.

Journal of autoimmunity - 1 Dec 2005

Liu Wei, Li Wei-Min, Gao Cheng, Sun Ning-Ling

Abstract excerpt

OBJECTIVE: Experimental autoimmune myocarditis (EAM) in rats is a T cell-mediated disorder and the involvement of Th1/Th2 unbalance has been demonstrated. This study was designed to test the hypothesis that 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor, atorvastatin, affects T cell-mediated autoimmunity through modulating the balance of Th1/Th2 and reduces the severity of EAM. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atorvastatin
Share to Heart Function Tests
Share to Heptanoic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Myocarditis

Share to Pyrroles

Share to Rats, Inbred Lew

Share to Th2 Cells

Source

Identifiers

PMID: 16242301
DOI: 10.1016/j.jaut.2005.06.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats.PMID 16242301Read ↗

ROCK inhibitor Y-27632 down-regulates Il-1β expression in mice with experimental autoimmune myocarditisSemantic proximity Read ↗

Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype.Semantic proximity Read ↗

Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.Semantic proximity Read ↗

Empagliflozin attenuates inflammation levels in autoimmune myocarditis through the STAT3 pathway and macrophage phenotype transformation.Semantic proximity Read ↗

STAT4 silencing underlies a novel inhibitory role of microRNA-141-3p in inflammation response of mice with experimental autoimmune myocarditisSemantic proximity Read ↗

Statins as modulators of regulatory T-cell biology.Semantic proximity Read ↗

Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.Semantic proximity Read ↗

Atorvastatin attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats postmyocardial infarction.Semantic proximity Read ↗

Ethyl Pyruvate Ameliorates Experimental Autoimmune Myocarditis.Semantic proximity Read ↗

Vitamin D receptor restricts T helper 2-biased inflammation in the heart.Semantic proximity Read ↗

Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.Semantic proximity Read ↗

Autoimmunity in heart disease: mechanisms and genetic susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.