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Article

HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival.

Cell death & disease - 25 May 2017

Lacher Sonja M, Bruttger Julia, Kalt Bettina, Berthelet Jean, Rajalingam Krishnaraj, Wörtge Simone, Waisman Ari

Abstract excerpt

Statins are a well-established family of drugs that lower cholesterol levels via the competitive inhibition of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). In addition, the pleiotropic anti-inflammatory effects of statins on T cells make them attractive as therapeutic drugs in T-cell-driven autoimmune disorders. Since statins do not exclusively target HMGCR and thus might have varying...

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Identifiers

PMID: 28542128
DOI: 10.1038/cddis.2017.221
PMCID: PMC5520735

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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