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Article

Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans.

Anesthesia and analgesia - 1 Jun 2011

Kayser Ernst-Bernhard, Suthammarak Wichit, Morgan Phil G, Sedensky Margaret M

Abstract excerpt

BACKGROUND: Complex I of the electron transport chain (ETC) is a possible target of volatile anesthetics (VAs). Complex I enzymatic activities are inhibited by VAs, and dysfunction of complex I can lead to hypersensitivity to VAs in worms and in people. Mutant analysis in Caenorhabditis (C.) elegans suggests that VAs may specifically interfere with complex I function at the binding site for its substrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electrophoresis, Gel, Two-Dimensional

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Source

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Identifiers

PMID: 21467554
DOI: 10.1213/ANE.0b013e3182121d37
PMCID: PMC3102776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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