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Article

Methylation of 23S ribosomal RNA due to carB, an antibiotic-resistance determinant from the carbomycin producer, Streptomyces thermotolerans.

European journal of biochemistry - 20 Apr 1990

Zalacain M, Cundliffe E

Abstract excerpt

A resistance gene, carB, originally isolated from the carbomycin-producing organism, Streptomyces thermotolerans, confers on Streptomyces lividans high-level resistance to the drug. However, ribosomes from S. lividans expressing carB show only moderate resistance to this macrolide in vitro, although they are highly resistant to the action of lincosamide antibiotics. The carB product monomethylates the amino group...

Topics

Bacterial Proteins
Cloning, Molecular
Drug Resistance, Microbial
Leucomycins
Methylation
Microbial Sensitivity Tests
Phenotype
RNA, Bacterial
RNA, Ribosomal
RNA, Ribosomal, 23S
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptomyces

Source

Identifiers

PMID: 1691981
DOI: 10.1111/j.1432-1033.1990.tb15460.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1691981-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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