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Article

Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.

Antimicrobial agents and chemotherapy - 1 Oct 2004

Novotny Guy W, Jakobsen Lene, Andersen Niels M, Poehlsgaard Jacob, Douthwaite Stephen

Abstract excerpt

Ketolides are the latest derivatives developed from the macrolide erythromycin to improve antimicrobial activity. All macrolides and ketolides bind to the 50S ribosomal subunit, where they come into contact with adenosine 2058 (A2058) within domain V of the 23S rRNA and block protein synthesis. An additional interaction at nucleotide A752 in the rRNA domain II is made via the synthetic carbamate-alkyl-aryl...

Topics

Anti-Bacterial Agents
Erythromycin
Escherichia coli
Ketolides
Microbial Sensitivity Tests
Models, Molecular
Mutagenesis, Site-Directed
Mutation
Plasmids
RNA, Ribosomal, 23S
Tylosin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15388419
DOI: 10.1128/AAC.48.10.3677-3683.2004
PMCID: PMC521900

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Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.PMID 15388419Read ↗

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