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Article

Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

Antimicrobial agents and chemotherapy - 1 Jun 2002

Liu Mingfu, Douthwaite Stephen

Abstract excerpt

Methylation of specific nucleotides in rRNA is one of the means by which bacteria achieve resistance to macrolides-lincosamides-streptogramin B (MLS(B)) and ketolide antibiotics. The degree of resistance is determined by how effectively the rRNA is methylated. We have implemented a bacterial system in which the rRNA methylations are defined, and in this study we investigate what effect Erm mono- and dimethylation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12019067
DOI: 10.1128/AAC.46.6.1629-1633.2002
PMCID: PMC127225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.PMID 12019067Read ↗

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