Article
Identification of a single base change in ribosomal RNA leading to erythromycin resistance.
The Journal of biological chemistry - 25 Apr 1992
Vannuffel P, Di Giambattista M, Morgan E A, Cocito C
Abstract excerpt
The molecular basis of a mutation conferring an erythromycin-resistance phenotype was explored, as an approach to the role of 23 S rRNA in the peptidyl-transferase activity of 50 S ribosomal subunits. Mutagenization of an Escherichia coli strain, which carried the multicopy plasmid pLC7-21 contai...
Topics
- Base Sequence
- Drug Resistance, Microbial
- Erythromycin
- Escherichia coli
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Operon
- Phenotype
- Plasmids
- RNA, Ribosomal, 23S