Article
The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Molecular cell - 1 Jul 2002
Hansen Jeffrey L, Ippolito Joseph A, Ban Nenad, Nissen Poul, Moore Peter B, Steitz Thomas A
Abstract excerpt
Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center. Their location suggests that they inhibit protein synthesis by blocking the egress of nascent polypeptides. The...
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